Gamma Aminobutyric Acid


Synonym

GABA

Definition

GABAisabiologicallyactiveaminoacidfoundinplants as well as in the brain and other animal tissues. One of the principle inhibitory amino acid neurotransmitters in the central nervous system. GABA acts as an agonist at two receptors, the GABAa receptor, which is a chloride channel, and the GABAb receptor, which is a G-protein linked receptor. Primary afferent depolarization in the central nervous system is thought to be mediated by the release of GABA at axo-axonic synapses. Activation of GABAa receptors by synaptically released GABA depolarizes the central terminals of afferent fibers, increasing their excitability. It is found primarily in inhibitory interneuros throughout the neuraxis.

► GABA Mechanisms and Descending Inhibitory Mechanisms

► GABA and Glycine in Spinal Nociceptive Processing

► Molecular Contributions to the Mechanism of Central Pain

► Nociceptors in the Orofacial Region (Temporo-mandibular Joint and Masseter Muscle)

► Somatic Pain

► Spinal Cord Nociception, Neurotrophins

► Stimulation-Produced Analgesia

► Thalamic Neurotransmitters and Neuromodulators

► Thalamic Plasticity and Chronic Pain